The cell polarity kinase Par1b/MARK2 activation selects specific NF-kB transcripts via phosphorylation of core mediator Med17/TRAP80

CCK stimulates mob-1 expression and NF-kB activation via protein kinase C and intracellular Ca21

Han, Bing, and Craig D. Logsdon. CCK stimulates mob-1 expression and NF-kB activation via protein kinase C and intracellular Ca21. Am. J. Physiol. Cell Physiol. 278: C344–C351, 2000.—Supraphysiological concentrations of cholecystokinin (CCK) induce chemokine expression in rat pancreatic acini through the activation of the transcription factor NF-kB. In the current study, the intracellular signa...

Vitamin C Inhibits NF-kB Activation by TNF Via the Activation of p38 Mitogen-Activated Protein Kinase

NF-kB activation induced by T cell receptoryCD28 costimulation is mediated by protein kinase C-u

Protein kinase C-u (PKCu) is a Ca21-independent member of the PKC family that is selectively expressed in skeletal muscle and T lymphocytes and plays an important role in T cell activation. However, the molecular basis for the important functions of PKCu in T cells and the manner in which it becomes coupled to the T cell receptorsignaling machinery are unknown. We addressed the functional relat...

Therapeutic Discovery A Novel Kinase Inhibitor of FADD Phosphorylation Chemosensitizes through the Inhibition of NF-kB

Fas-associated protein with death domain (FADD) is a cytosolic adapter protein essential for mediating death receptor–induced apoptosis. It has also been implicated in a number of nonapoptotic activities including embryogenesis, cell-cycle progression, cell proliferation, and tumorigenesis. Our recent studies have shown that high levels of phosphorylated FADD (p-FADD) in tumor cells correlate w...

NF-kB Activation by Double-Stranded-RNA-Activated Protein Kinase (PKR) Is Mediated through NF-kB-Inducing Kinase and IkB Kinase